Here's site that can serve as a (reasonably light) benchmark: https://tiki.org This video shows how EpiphanyDevel "technology preview" (flatpak version from gnome-nightly), shown on the left, struggles to scroll smoothly and to follow the mousewheel's events (or the mouse cursor's drag on the scrollbar), whereas Firefox (shown on the right) has no problem and remains butter-smooth: https://youtu.be/O6ixlqzSDwA The difference is more subtle than bug #215045 or bug #221738, but the jankiness can still be felt.
This can no longer be observed in Gnome Web 44.2/ WebKitGTK 2.40.1. Perhaps fixed already?
It might be worth retesting now with Skia